Oncology
Translational Research in Child and Adolescent Cancer
Josep Sánchez de Toledo
Researchers
Soledad Gallego, Cristina Díaz de Heredia, Anna Llort, Constantino Sábado, Luis Gros, Josep Roma, Miquel F Segura, Aroa Soriano
Researchers in training
Ana Almazán, Luz Jubierre, Carla Molist, Laia París, Irina Giralt, Ariadna Boloix, Patricia Zarsosa
Technician
Isaac Vidal
SUMMARY
During 2014, the group of Translational Research in Pediatric Cancer has been consolidated and recognized by the Generalitat de Catalunya as an “emerging group”. The group has participated in 9 publications and two of the Principal Investigators have been awarded with grants from the Instituto de Salud Carlos III. Moreover, one of the post-graduate researchers has been awarded with a VHIR predoctoral fellowship. In addition, the group has established and consolidated agreements with biotech companies to test and develop new therapeutic tools against the most aggressive pediatric solid tumors.
PUBLICATIONS
- Velasco P, Clemente M, Lorite R, Ventura MC, Gros L, Sanchez de Toledo J, Gallego S. The role of leptin in diencephalic syndrome. Pediatrics. 2014 Jan;133(1):e263-6. IF: 5.297
- Diaz de Heredia C, Gonzalez M, Verdeguer A, Elorza I, Rodriguez A, Martinez A, Perez JM, Badell I, Gonzalez ME, Olive T, Fernandez JM, Maldonado MS, Diaz MA, Sanchez de Toledo J. Long-term outcome and prognostic factors of unrelated cord blood transplantation in children with haematological malignancies: a retrospective study using the Spanish Working Party for BMT in Children (GETMON) database. Bone Marrow Transplant. 2014 Jun;49(6):767-72. IF: 3.466
- Planells-Ferrer L, Urresti J, Soriano A, Reix S, Murphy DM, Ferreres JC, Borràs F, Gallego S, Stallings RL, Moubarak RS, Segura MF, Comella JX. MYCN repression of Lifeguard/FAIM2 enhances neuroblastoma aggressiveness. Cell Death Dis. 2014 Sep 4;5:e1401. IF: 5.177
- Huertas-Martínez J, Rello-Varona S, Herrero-Martín D, Barrau I, García-Monclús S, Sáinz-Jaspeado M, Lagares-Tena L, Núñez-Álvarez Y, Mateo-Lozano S, Mora J, Roma J, Toran N, Moran S, López-Alemany R, Gallego S, Esteller M, Peinado MA, Del Muro XG, Tirado OM. Caveolin-1 is down-regulated in alveolar rhabdomyosarcomas and negatively regulates tumor growth. Oncotarget. 2014 Oct 30;5(20):9744-55. IF: 6.627
- Almazán-Moga A, Roma J, Molist C, Vidal I, Jubierre L, Soriano A, Segura MF, Llort A, Sánchez de Toledo J, Gallego S. Optimization of rhabdomyosarcoma disseminated disease assessment by flow cytometry. Cytometry A. 2014 Dec;85(12):1020-9. IF: 3.066
MAIN RESEARCH PROJECTS
View- TITLE: NOTCH pathway inhibition as therapeutic target in rhabdomyosarcoma
PRINCIPAL INVESTIGATOR: Soledad Gallego
FINANCIAL ENTITY: Fundació Marató TV3 (N. Proyecto 20101310)
DURATION FROM: 2011 TO: 2014
AMOUNT: 180.000€ - TITLE: La subpoblación de células iniciadoras de tumor como nueva diana terapéutica en el rabdomiosarcoma.
PRINCIPAL INVESTIGATOR: Soledad Gallego
FINANCIAL ENTITY: Fondo Investigaciones Sanitarias (N. Proyecto PI11/00740).
DURATION FROM: 2012 TO: 2015
AMOUNT: 82.000€ - TITLE: Functional role of microRNA in high-risk Neuroblastoma
PRINCIPAL INVESTIGATOR: Dr. Miguel F. Segura
FINANCIAL ENTITY: Instituto de Salud Carlos III, Ministerio de Economía y Competividad
DURATION FROM: 2012 TO: 2014
AMOUNT: 120.000 € - TITLE: Novel miRNA-based therapy for chemoresistant neuroblastomas
PRINCIPAL INVESTIGATOR: Dr. Miguel F. Segura
FINANCIAL ENTITY: Marie Curie Career Integration Grants.
DURACIÓN: 2013-2016.
AMOUNT: 100.000 € - TITLE: Red Temática de Investigación Cooperativa en Cáncer (RTICC)
PRINCIPAL INVESTIGATOR: José Sánchez de Toledo Codina
FINANCIAL ENTITY: Instituto de Salud Carlos III
DURACIÓN: 2013-2016
AMOUNT: 184.000 €