Oncology
Biomedical Research in Gynecology
Antonio Gil Moreno
Researchers
Anna Santamaria Margalef, Eva Colás Ortega, Xavier Santamaria, Ángel Garcia, Assumpció Pérez Benavente, Sílvia Cabrera, Berta Díaz, José Luis Sánchez, Javier de la Torre, Cristina Centeno, Silvia Franco, María Elena Suárez, José Luis Poza, Blanca Gil, Sabina Salicrú, Montserrat Cubo, Sira Capote, Laura Mañalich
Researchers in training
Tatiana Altadill Vallespí, Irene Campoy Moncayo, Laura Devis Jauregui, Elena Martínez Garcia, Blanca Majem Cavaller, Júlia Vallvé Juanico, Lucia Lanau Angulo, Marta Ibáñez, Núria Masià, Cristian Baron
Technician and administrative staff
Gabriel Tamayo Ballesteros, Elisabet Olivan Riera
SUMMARY
The long-standing Biomedical Research and Translational Oncology Unit has been restructured during 2014, mostly due to the departure of its director, Dr. Jaume Reventós. The outstanding research on gynaecological pathologies is now conducted by the Biomedical Research Group in Gynaecology, leaded by Dr. Antonio Gil Moreno. Dr. Gil has managed to increase the already high crosstalk between clinicians and basic and translational researchers generating a more fruitful research environment. Apart from his duties as director of the group, Dr. Gil is mostly dedicated to endometrial cancer translational and clinical research within the group.
During this year, the group also incorporated a young principal investigator, Dr. Anna Santamaria Margalef, who was recipient of a Miguel Servet Grant. She is now specially dedicated to ovarian cancer.
Together, they have managed to provide the group with a more directed research towards improving the management of endometrial and ovarian cancer patients, as well as endometriosis.
PUBLICATIONS
- Alonso-Alconada L, Eritja N, Muinelo-Romay L, Barbazan J, Lopez-Lopez R, Matias-Guiu X, Gil-Moreno A, Dolcet X, Abal M. ETV5 transcription program links BDNF and promotion of EMT at invasive front of endometrial carcinomas.Carcinogenesis. 2014 Sep 18
IF 5.266 - Lorena Alonso-Alconada, Laura Muinelo-Romay, Kadri Madissoo, Antonio Diaz-Lopez, Camilla Krakstad, Jone Trovik, Elisabeth Wik, Dharani Hapangama, Lieve Coenegrachts, Amparo Cano, Antonio Gil-Moreno, Luis Chiva, Juan Cueva, Maria Vieito, Eugenia Ortega, Javier Mariscal, Eva Colas, Josep Castellvi, Maite Cusido, Xavier Dolcet, Hans W Nijman, Tjalling Bosse, John A Green, Andrea Romano, Jaume Reventos, Rafael Lopez-Lopez, Helga B Salvesen, Frederic Amant, Xavier Matias-Guiu, Gema Moreno-Bueno, Miguel Abal* (ENITEC Consortium). Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer. Mol Cancer Res. 2014. A. IF: 4,502
- Llauradó M, Majem B, Altadill T, Lanau L, Castellví J, Sánchez-Iglesias JL, Cabrera S, De la Torre J, Díaz-Feijoo B, Pérez-Benavente A, Colás E, Olivan M, Doll A, Alameda F, Matias-Guiu X, Moreno-Bueno G, Carey MS, Del Campo JM, Gil-Moreno A, Reventós J, Rigau M. MicroRNAs as prognostic markers in ovarian cancer. Mol Cell Endocrinol. 2014 Jun. 390(1-2):73-84. R, IF 4,039
- Díaz-Feijoo B, Gil-Ibáñez B, Pérez-Benavente A, Martínez-Gómez X, Colás E, Sánchez-Iglesias JL, Cabrera-Díaz S, Puig-Puig O, Magrina JF, Gil-Moreno A.Comparison of robotic-assisted vs conventional laparoscopy for extraperitoneal paraaortic lymphadenectomy. Gynecol Oncol. 2014 Jan; 132(1):98-101. A. IF: 3,929
- Bonifaci N, Colas E, Serra Musach J, Karbalai N, Brunet J, Gomez A, Esteller M, Fernandez-Taboada E, Berenguer A, Reventos J, Muller-Myhsok B, Amundadottir L, Duell EJ, Angel Pujana M. Integrating gene expression and epidemiological data for the discovery of genetic interactions associated with cancer risk. Carcinogenesis. 2014 Mar;35(3):578-85
IF: 5,334
MAIN RESEARCH PROJECTS
View- Title of the Project: Desarrollo de Marcadores y Terapias en Cáncer de Endometrio Avanzado
Funding source: Fondo de Investigación Sanitaria PI14/02043
Principal Investigator: Antonio Gil Moreno
Duration: 2015 – 2017
Financing: 147.620,00 € - Title of the Project: Validación de Anexina2 como predictor de recidiva en el cáncer de endometrio. Diseño de nuevas estrategias terapéuticas (ANXARECU)
Funding source: Ministerio de Economica y Competitividad
Principal Investigator: Althia, FORMUNE, Xavier Matias-Guiu, Jaume Reventós
Duration: 2014 – 2016
Financing: 107.350 (VHIR) - Title of the Project: Genomic approach for individualizing endometrial cancer diagnosis, prognosis and treatment.
Funding source: Fundació La Marató de TV3. 2C2013.
Principal Investigators: Xavier Matias-Guiu, Antonio Gil Moreno, José Palacios y Gema Moreno
Duration: 2013 – 2016
Financing: 397.540 € (99.442,50 € VHIR) - Title of the Project: Identification of miRNA profiles associated with short and long survival of ovarian cancer advanced patients for the improvement of their treatment.
Funding source: FundacióSantiago Dexeus Font
Principal Investigator: Jaume Reventós Puigjaner
Duration: 2013-2014
Financing: 6.000 € - Title of the Project: Alteraciones moleculares relacionadas con la progresión tumoral en el cáncer de endometrio.
Funding source: AECC. Convenio entre la Fundación científica de la Asociación Española contra el Cáncer (AECC) y la Fundació Hospital universitari Vall d’Hebron Institut de Recerca en materia de ayudas para la financiación de grupos estables para la investigación oncológica.
Principal Investigator (coordinator): Jaume Reventós Puigjaner.
Duration: 2011-2015
Financing: 1.200.000,00 € (256.500,00 € VHIR)
PATENTS
- Method to predict risk of recurrence in endometrial carcinoma.
WIPO Patent Application: Application Number: EP 14155510.2 Publication Date: 18.02.2014 Filing Date: Priority Date:
Inventors: Xavier Matias-Guiu, Javier Dolcet, Jaume Reventós, Eva Colás, Jaime Prat Diaz, José Palacios, Miguel Abal, Rafael López López, Gema Moreno, Antonio Gil.