VHIO

Thoracic Tumors Group

Enriqueta Felip

Medical Oncologists
Susana Cedrés, Álex Martínez, Alejandro Navarro

Study Coordinators
Marta Beltrán, Lluïsa Carbonell, Marta Malo, Lidia Martínez de Arenzana, Adelaida Piera

Data Manager
Soraya Fernández Ruiz

SUMMARY

The main focus of the Thoracic Tumors Group is to tackle various aspects of lung cancer, the most frequently diagnosed tumor to date. Our group concentrates on a number of areas ranging from disease prevention, early detection, more accurate techniques in diagnosis and staging to advancing precision medicine and treatment of lung cancer. We are also highly dedicated to our program which focuses on targeted therapies in patients with specific molecular alterations and immunotherapy strategies.

Main highlights this year are as follows: 500 new lung cancer patients including 20 cases of mesothelioma and 5 of thymoma, fostering close multidisciplinary collaboration through our established lung cancer tumors committee which convenes twice a week, the implementation of pharmacogenomic approaches in advanced NSCLC in collaboration with VHIO’s Cancer Genomics group as well as the Vall d’Hebron University Hospital Pathology Service (working with Javier Hernández and Irene Sansano), our involvement in exome sequencing in NSCLC patients, the analysis of PDL1 expression in mesothelioma patients, as well as our active participation in two New England Journal of Medicine papers published in 2014 including ALK positive patients (Shaw A.T. et al., N Engl J Med 2014, and, Solomon B.J. et al, N Engl J Med 2014). We have also organzied the 2014 European Lung Cancer Conference (ELCC), 26 – 29 March, Geneva, Switzerland.

PUBLICATIONS

Total 20.
Impact Factor 203.17
Average I.F. 10.156

  • Jänne PA , Cohen RB, Laird AD, Macé S, Engelman JA, Ruiz-Soto R, Rockich K, Xu J, Shapiro GI, Martinez P, Felip E. Phase I safety and pharmacokinetic study of the PI3K/mTOR inhibitor SAR245409 (XL765) in combination with erlotinib in patients with advanced solid tumors. J Thorac Oncol. 2014 Mar; 9(3):316-23.
  • Shaw A, Kim D, Mehra R, Tan D, Felip E, Chow L, Camidge D, Vansteenkiste J, Sharma S, De Pas T,
    Riely G, Solomon B, Wolf J, Thomas M, Schuler M, Liu G, Santoro A, Lau YY, goldwasse M, Boral A, Engelman J. Ceritinib in ALK-rearranged non-small-cell lung cancer. N Engl J Med. 2014. 27; 370 (13):1189-97.
  • Kerr K, Bubendorf L, Edelman M, Marchetti A, Mok T, Novello S, O’Byrne K, Stahel R, Peters S, Felip E. 2nd ESMO Consensus Conference on Lung Cancer: Pathology and Molecular Biomarkers for Non-small-cell lung cancer. Ann Oncol. Apr. 2014.
  • Novello S, Besse B, Felip E, Barlesi F, Mazières J, Zalcman G, Von Pawel J, Reck M, Capuzzo F, Ferry D, Carcereny E, Santoro A, Garcia-Ribas I, Scagliotti G, Soria JC. A phase II randomized study evaluating the addition of iniparib to gemcitabine plus cisplatin as first-line therapy for metatstatic non-small-cell lung cancer. Ann Oncol. 2014, Aug.
  • Solomon BJ, Mok T, Kim DW, Wu YL; Nakagawa K; Mekhail T;Felip E; Capuzzo F; Paolini J; Usari T; Iyer S; Reisman A; Wilner KD; Tursi J; Blackhall F; PROFILE 1014 Investigators. First-line crizotinib versus chemotherapy in ALK-positive lung cancer. N Engl J Med. 2014 Dec 4; 371 (23): 2167-77.

MAIN RESEARCH PROJECTS

  • Deep sequencing using Illumina of the coding regions of 17 genes (EGFR, KRAS, NRAS, HRAS, CRAF, HER2, HER4, BRAF, PIK3CA, AKT2, b-catenin, MET, NOTCH1, PRMT5, ALK, TP53 and LKB1) in tumor samples from EGFR-mut, ALK+ patients (A. Vivancos, J. Hernandez).
  • Assessment of FGFR1 amplification by FISH analysis in SCC (C. Aura, J. Jimenez) ASCO12.
  • PDL1 expression by IHC in lung cancer (P. Nuciforo).
  • Whole exome sequencing in triple-negative ADC (A. Vivancos).
  • Analysis of potential mechanisms of resistance in tumors from oncogene-addicted patients (M. Sánchez-Céspedes, A. Vivancos).