VHIO

Molecular Oncology Group

Paolo Nuciforo

Attending Physicians
Claudia Aura, Mª Alejandra Gabaldón, Ludmila Prudkin

Laboratory Supervisor
Jose Jiménez

Laboratory Assistant
Mª Ángeles Díaz

Technicians
Mª del Carmen Díaz, Paola Martínez, Nerea Peiró, Gertrudis Sánchez, César Sevillano

Administration
Mª Alejandra Iglesias

SUMMARY

The Molecular Oncology Group’s mission is to apply state-of-the-art tissue-based technologies to basic, translational, and clinical research with a clear focus on developing and validating novel tumor biomarkers for precision cancer medicine. As one of VHIO´s Core Facilities, we currently provide support to more than 160 clinical trials conducted at Vall d’Hebron, representing ~70% of all trials open in our institution. Our activities relating to clinical trials range from the coordination of sample collection and biorepository, developing and running multiple assays for real-time patient inclusion, as well as pharmacodynamic monitoring and dose finding.

In 2014, our laboratory successfully maintained the prestigious ISO15189 quality accreditation for running tissue-based analyses on clinical samples. During this year, we have performed over 2700 molecular determinations on samples for patient inclusion into clinical trials and over 14,000 tests to support basic and translation research programs, with a ~40% overall increase in testing activity as compared to 2013. We have also been the central laboratory for 8 national and international studies.

PUBLICATIONS

Total 8.
Impact Factor 68.753
Average I.F. 8.594

  • High HER2 expression correlates with response to the combination of lapatinib and trastuzumab. Scaltriti M, Nuciforo P, Bradbury I, Sperinde J, Agbor-Tarh D, Campbell C, Chenna A, Winslow J, Serra V, Parra JL, Prudkin L, Jimenez J, Aura C, Harbeck N, Pusztai L, Ellis CE, Eidtmann H, Arribas J, Cortes J, De Azambuja E, Piccart M, Baselga J. Clin Cancer Res. 2014 Dec 2. pii: clincanres.1824.2014. [Epub ahead of print]
  • Effect of p95HER2/611CTF on the response to trastuzumab and chemotherapy. Parra-Palau JL, Morancho B, Peg V, Escorihuela M, Scaltriti M, Vicario R, Zacarias-Fluck M, Pedersen K, Pandiella A, Nuciforo P, Serra V, Cortés J, Baselga J, Perou CM, Prat A, Rubio IT, Arribas J. J Natl Cancer Inst. 2014 Sep 24;106(11). pii: dju291. doi: 10.1093/jnci/dju291. Print 2014 Nov.
  • Obstacles to precision oncology: confronting current factors affecting the successful introduction of biomarkers to the clinic. Prudkin L, Nuciforo P. Cell Oncol (Dordr). 2014 Sep 4. [Epub ahead of print]
  • Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle. De Mattos-Arruda L, Weigelt B, Cortes J, Won HH, Ng CK, Nuciforo P, Bidard FC, Aura C, Saura C, Peg V, Piscuoglio S, Oliveira M, Smolders Y, Patel P, Norton L, Tabernero J, Berger MF, Seoane J, Reis-Filho JS. Ann Oncol. 2014 Sep;25(9):1729-35. doi: 10.1093/annonc/mdu239. Epub 2014 Jul 9.
  • Genomic aberrations in the FGFR pathway: opportunities for targeted therapies in solid tumors. Dienstmann R, Rodon J, Prat A, Perez-Garcia J, Adamo B, Felip E, Cortes J, Iafrate AJ,Nuciforo P, Tabernero J. Ann Oncol. 2014 Mar;25(3):552-63. doi: 10.1093/annonc/mdt419. Epub 2013 Nov 20.