Neurosciences
Neurotraumatology and Neurosurgery Research Group (UNINN)
Juan Sahuquillo
Researchers
Fuat Arikan Abello, Marcelino Báguena Martínez, María Dolores de la Calzada Álvarez, Alejandro Ferré Masó, Francisco Ramón Martínez Ricarte, Dulce María Moncho Rodríguez, Francisca Munar Bauza, Miriam de Nadal Clanchet, M. Antonia Poca Pastor, Marylin Riveiro Vilaboa, Ángel Robles González, Maria Sueiras Gil, Ramón Torné, Jordi Vilalta Castan
Researchers in training
Lidia Castro González, Victoria Cañas Barón, Tamara Martínez Valverde, Gemma Mur Bonet, Irina Andreea Radoi, Ángela Sánchez Guerrero, Mª Angeles Vidal Jorge
Nursing, Technical and administrative staff
Mercedes Arribas Serrano, Pilar Mancera, Lourdes Expósito Mozas, Olga Mestres Soler, Noelia Montoya Clemente, Joana Segura Segura
SUMMARY
In the laboratory, our group has been successful in extracting and culturing human adult neural stem cells from the subventricular zone, a major reservoir, giving support to one of our emerging research lines dedicated to slow disease progression and functional improvement in patients with traumatic brain injury, spinal cord injury, and stroke. Also, we have shown for the first time in patients with post-traumatic brain contusions that the sulfonylurea 1-receptor regulating both TRPM4 and Kir6.2 ionic channels is significantly overexpressed in the injured brain and is especially prominent in neurons and endothelial cells. Our findings reveal opportunities to act therapeutically on the mechanisms of growth of traumatic contusions and reduce the number of patients with poor neurological outcome. Our group has proposed a new classification of the disturbances in the energy metabolism in patients with acute brain injuries based on microdialysis findings.
We have significantly increased our participation in the development of international guidelines and consensus conferences in the field of traumatic brain injury, and we have entered the FP7 project CENTER-TBI (https://www.center-tbi.eu). We have established strong synergies and active collaboration with the Comparative Neurobiology research group at the University of Valencia (Dr. J. M. García–Verdugo) and with the Department of Neurosurgery, University of Maryland School of Medicine, Baltimore (Dr. JM. Simard).
PUBLICATIONS
- Skolnick BE, Maas AI, Narayan RK, van der Hoop RG, MacAllister T, Ward JD, Nelson NR, Stocchetti N for the SYNAPSE Trial Investigators. A Clinical Trial of Progesterone for Severe Traumatic Brain Injury. N Eng J Med 2014;371:2467-76
- Devereaux PJ, Mrkobrada M, Sessler DI, Leslie K, Alonso-Coello P, Kurz A; POISE-2 Investigators. Aspirin in patients undergoing noncardiac surgery. N Engl J Med 2014 Apr 17;370(16):1494-503
- Garg AX, Kurz A, Sessler DI, Cuerden M, Robinson A, Mrkobrada M, Parikh CR, Mizera R, Jones PM, Tiboni M, Font A, Cegarra V, Rojas Gomez MF, MD; Meyhoff CS, VanHelder T, Chan MTV, Torres D, Parlow J, for the POISE-2 Investigators. Perioperative aspirin and clonidine and risk of acute kidney injury: a randomized clinical trial. JAMA-J. Am. Med. Assoc 2014;312(21):2254-64
- Stover JF, Belli A, Boret H, Bulters D, Sahuquillo J, Schmutzhard E, Zavala E, Ungerstedt U, Schinzel R, Tegtmeier F; NOSTRA Investigators. Nitric oxide synthase inhibition with the antipterin VAS203 improves outcome in moderate and severe traumatic brain injury: a placebo-controlled randomized Phase IIa trial (NOSTRA). J Neurotrauma 2014 Oct 1;31(19):1599-606
- Sahuquillo J, Merino MA, Sánchez-Guerrero A, Arikan F, Vidal-Jorge M, Martínez-Valverde T, Rey A, Riveiro M, Poca MA. Lactate and the lactate-to-pyruvate molar ratio cannot be used as independent biomarkers for monitoring brain energetic metabolism: a microdialysis study in patients with traumatic brain injuries. Plos One July 2014;9(7):e102540
MAIN RESEARCH PROJECTS
View- FIS PI13/02397: Lesiones estructurales y repercusiones neuropsicologicas en el traumatismo craneoencefálico leve
PI: M. Antonia Poca
Duration: 2014 – 2016 - Fundació La Marató de TV3 479/C/2012: Brain repair after stroke: Magnetic field-mediated stem cell migration.
PI: Juan Sahuquillo
Duration: 2013 – 2015 - FIS PI11/00700: High-resolution microdialysis to detect mitochondrial failure after traumatic brain injury: a promising new paradigm for understanding pathophysiology and treating metabolic dysfunction.
PI: Juan Sahuquillo
Duration: 2012 – 2015 - AECC-GE2010-07: Molecular mechanisms involved in the genesis of the glioma and study of the tumoral stem cells. Identification of new therapeutic targets and markers for the stratification in patients and response to drugs.
Coordinator: Joan Seoane
PI: Juan Sahuquillo
Duration: 2011 – 2017 - FIS PI10/00302: Applications of high-resolution microdialysis to define the molecular profile of post-traumatic and ischemic brain edema and the contribution of non-selective SUR1-regulated NCCa-ATP channels to its formation.
PI: M. Antònia Poca
Duration: 2011 – 2014