Oncology
Molecular Pathology
Santiago Ramón y Cajal
Researchers
Trond Aasen, Margarita Alberola Ferranti, Elena Allende Monclús, Barbara Castellana Esteban, Josep Castellví Vives, Mª Carme Dinarès Fernández, Berta Ferrer Fàbrega, Joan Carles Ferreres Piñas, Angel García Jiménez, Marta Garrido Pontnou, Javier Hernández Losa, Carmela Iglesias i Felip, Stefania Landolfi, Elena Antima Martínez Saez, Vicente Peg Cámara, Cleofé Romagosa Pérez-Portabella, Mª Teresa Salcedo Allende, Irene Sansano Valero, Marta Sese Faustino, Natalia Tallada Serra, Inés de Torres Ramírez
Researchers in training
Andrea Feliciano Aguirre, Claudia Salat Canela, Alba Martínez Diaz
Technicians and nursing
Rosó Marès Pagès, Isabel Espinosa Sanahuja, Laura Fernández Cabré, Maria Rosa Somoza Lopez de Haro, Teresa Moliné Marimón
SUMMARY
Our group is interested in identifying new factors that confer resistance to cellular stress to tumor cells, factors that may be inhibited and become novel therapeutic targets. In this context, we focused on the association between the phosphorylated form of the eukaryotic translation initiation factor (eIF4E) and cellular resistance. Moreover, we have been working on the design of new and more potent MNK1/2 inhibitors in collaboration with Grup d’Enginyeria Molecular in IQS. Other studies are focused on the identification and validation of new factors upregulated after hypoxia and other metabolic inhibitors, by RNA-seq approach.
On the other hand, we have analyzed the function of YB-1 in breast cancer and discovered a novel interplay between YB-1 and IL-6 regulating EMT and other metastatic features. The group is also interested in the role and regulation of gap junctions in cancer and disease and in 2014 we made significant advancement in this field, some of which has already been published in the journal Cell Communication and Signalling.
PUBLICATIONS
- Perucho L, Artero-Castro A, Guerrero S, Ramon Y Cajal S, LLeonart ME, Wang ZQ. RPLP1, a Crucial Ribosomal Protein for Embryonic Development of the Nervous System. PLoS One. 2014 Jun 24;9(6):
- Salat-Canela C, Sese M, Peula C, Ramon y Cajal S, Aasen T. Internal translation of the connexin 43 transcript. Cell Commun Signal. 2014 May 8;12:31.
- Ramón y Cajal S, De Mattos-Arruda L, Sonenberg N, Cortés J, Peg V. The intra tumor heterogeneity of cell signaling factors in breast cancer: p4E-BP1 and peIF4E are diffusely expressed and are real potential targets. Clin Transl Oncol. 2014 Nov;16(11):937-41.
- Simonetti S, Serrano C, Hernandez-Losa C, Bague S, Orellana R, Valverde C, Lleonart ME, Aizpurua M, Carles J, Ramon Y Cajal S, Romagosa C. Schwannomas, benign tumors with a senescent phenotype. Histol Histopathol. 2014 Jun;29(6):721-30.
- Rodrigues P, Macaya I, Bazzocco S, Mazzolini R, Andretta E, Dopeso H, Mateo-Lozano S, Bilic J, Carton-Garcia F, Nieto R, Suarez-Lopez L, Afonso E, Landolfi S, Hernandez-Losa J, Kobayashi K, Cajal SR, Tabernero J, Tebbutt NC, Mariadason JM, Schwartz S Jr, et al. RHOA inactivation enhances Wnt signalling and promotes colorectal cancer. Nat Commun. 2014 Nov 21;5:5458. doi: 10.1038/ncomms6458. IF: 10,742
MAIN RESEARCH PROJECTS
View- Red Temática de Investigación Cooperativa en Cáncer (RTICC)
PI: Ramón y Cajal Agüeras, Santiago
Funding agency: Fondo de Investigación Sanitaria
Reference: RD12/0036/0057
Duration: from 2013 to 2016 - Estudio del factor elF4E y factores de la vía de síntesis de proteínas cap-independiente en tumores humanos: correlación con hipoxia, pronóstico e identificación de dianas terapéuticas
PI: Ramón y Cajal Agüeras, Santiago
Funding agency: Fondo de Investigación Sanitaria
Reference: PI11/00185
Duration: from 2012 to 2014 - Anatomia Patològica (GRC)
PI: Ramón y Cajal Agüeras, Santiago
Funding agency: AGAUR
Reference: 2014 SGR 1131
Funding: 0,00 € - Patologia Molecular
PI: Ramón y Cajal Agüeras, Santiago
Funding agency: AGAUR
Reference: 2009 SGR 756
Duration: from 2010 to 2014 - RETICS de Biobancos
PI: Ramón y Cajal Agüeras, Santiago
Funding agency: Fondo de Investigación Sanitaria
Reference: RD09/0076/00066
Duration: from 2010 to 2014 - RTICC – Red Temática de Investigación cooperativa de cáncer
PI: Ramón y Cajal Agüeras, Santiago
Funding agency: Fondo de Investigación Sanitaria
Reference: RD06/0020/0104
Duration: from 2007 to 2014