Respiratory and Systemic Diseases

Systemic Diseases

Miquel Vilardell

Researchers
Juan José de Agustin de Oro, Cayetano Alegre de Miquel, Eva Balada Prades, Jose Angel Bosch Gil, Segundo Bujan Rivas, Victòria Cardona Dahl, Josefina Cortes Hernandez, Vicenç Fonollosa Pla, Mar Guilarte Clavero, Antonio Julia Cano, Moisés Labrador Horrillo, Joan Lima Ruiz, Maria America Lopez Lasanta, Olga Luengo Sanchez, Sara Marsal Barril, Fernando Martínez Valle, Consuelo Modesto Caballero, José Ordi Ros, José Pardos Gea, Jorge Pérez López, Mari Carmen Pérez Bocanegra, Anna Sala Cunill, Antonio San Jose Laporte, Agustí Sellas Fernández, Albert Selva O’Callaghan, Carmen Pilar Simeón i Aznar, Roser Solans Laque, Cristina Solé Marce, Ernesto Trallero Araguas

Researchers in training
Arnald Alonso Pastor, Laura Bernal Peix, Alfredo Guillen Del Castillo, Iago Pinal Fernández, Marc Ramentol Sintas

Nursing, Technical, and Administrative Staff
Adria Aterido Ballonga, Maria Lidon Felip Pascual, Daniel Granados Pino, Carla Larroy Margalejo, Antoni Moliné Pareja, Nuria Palau Balaña, Estefania Quesada Masachs, Susana Sanchez Torres, Raul Tortosa Méndez

SUMMARY

We have detected that the transcript levels of three epigenetically regulated genes (ITGAL, PRF1, and CD70) are overexpressed in CD4+ T cells from patients with systemic lupus erythematosus. We have also identified neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for lupus nephritis. Furthermore, we have found out that cortactin is a new target antigen for patients with autoimmune diseases, especially for patients with polymyositis or immune-mediated necrotizing myopathy. Thus, anti-cortactin antibodies can be considered as a new myositis-associated serological marker. Finally, we have also established (by using a new ELISA and immunoblot techniques) the association between the presence of anti-MDA-5 antibodies and rapidly-progressive interstitial pneumonia in patients with dermatomyositis.

PUBLICATIONS

Total 32.
Impact Factor 123.766
Average I.F. 3.868

  • Labrador-Horrillo M, Martínez MA, Selva-O’Callaghan A, Trallero-Araguás E, Grau-Junyent JM, Vilardell-Tarrés M, Juarez C. Identification of a novel myositis-associated antibody directed against cortactin. Autoimmun Rev. 2014 Oct;13(10):1008-1012.
  • Torres-Salido MT, Cortés-Hernández J, Vidal X, Pedrosa A, Vilardell-Tarrés M, Ordi-Ros J. Neutrophil gelatinase-associated lipocalin as a biomarker for lupus nephritis. Nephrol Dial Transplant. 2014 Sep;29(9):1740-9.
  • Balada E, Castro-Marrero J, Felip L, Ordi-Ros J, Vilardell-Tarrés M. Clinical and serological findings associated with the expression of ITGAL, PRF1, and CD70 in systemic lupus erythematosus. Clin Exp Rheumatol. 2014 Jan-Feb;32(1):113-6.
  • Pinal-Fernandez I, Selva-O’Callaghan A, Fernandez-Codina A, Martinez-Gomez X, Rodrigo-Pendas J, Perez-Lopez J, Vilardell-Tarres M. “Pregnancy in adult-onset idiopathic inflammatory myopathy”: report from a cohort of myositis patients from a single center. Semin Arthritis Rheum. 2014 Oct;44(2):234-40.
  • Labrador-Horrillo M, Martinez MA, Selva-O’Callaghan A, Trallero-Araguas E, Balada E, Vilardell-Tarres M, Juárez C. Anti-MDA5 Antibodies in a Large Mediterranean Population of Adults with Dermatomyositis. J Immunol Res. 2014; 2014:290797.

 

View all the publications

MAIN RESEARCH PROJECTS

  • Randomized controlled study to evaluate the safety and efficacy of rivaroxaban for the secondary thromboprophilaxis in Antiphospholipid Syndrome (SAP02)
    PI: Dr J Cortés –Hernández
    Finanacial support: Bayer and Catalan Lupus Fundation
    From 2013-2016
  • Discoid Lupus: Dissection by Microarray
    PI: Dr J Cortés-Hernández
    FIS PI10-02234
    From: 2010-2014
  • TIF1 proteins and paraneoplastic dermatomyositis
    PI: Dr Ernesto Trallero Arguas
    FIS PI12-01320
    From: 2013-2015
  • Global genomic analysis of the rheumatoid and Psoriatic arthritis.
    PI: Dr Sara Marsal Borrell
    FIS PI11-01371
    From: 2012-2015
  • Type I interferons and autoimunity: 2-5A/RNAsa L pathway in Systemic erythematosus Patients.
    PI: Dr M Vilardell-Tarres
    FIS PI12-01002
    From: 2013-2015

 

View all the research projects

PATENTS

  • Title: Urinary Neurophiline 1 (NRP-1) as prognostic marker for lupus nephritis Authors: Josep Ordi-Ros, Josefina Cortés-Hernández, María Teresa Torres-Salido, Anna Solà, Georgina Hotter.
    Number: P201331051 .