Digestive and Liver Diseases
Digestive Transplants
Ramon Charco
Researchers
Joaquin Balsells Valls, Itxarone Izaskun Bilbao Aguirre, Mireia Caralt Barba, Cristina Dopazo Taboada, José Luis Lázaro Fernández, Gonzalo Sapisochin Cantis, Mar Miserachs Barba, Jesús Quintero Bernabeu, Laia Blanco Cuso, José Andrés Molino Gahete
SUMMARY
Our group is mainly focused on immunosuppression in liver transplantation and treatment of hepatocarcinoma and cholangiocarcinoma on cirrhosis. The new research lines are Microbiota and liver transplantation and liver bioengineering.
PUBLICATIONS
Intrahepatic cholangiocarcinoma or mixed hepatocellular-cholangiocarcinoma in patients undergoing liver transplantation: a Spanish matched cohort multicenter study.
Sapisochin G, de Lope CR, Gastaca M, de Urbina JO, López-Andujar R, Palacios F, Ramos E, Fabregat J, Castroagudín JF, Varo E, Pons JA, Parrilla P, González-Diéguez ML, Rodriguez M, Otero A, Vazquez MA, Zozaya G, Herrero JI, Antolin GS, Perez B, Ciria R, Rufian S, Fundora Y, Ferron JA, Guiberteau A, Blanco G, Varona MA, Barrera MA, Suarez MA, Santoyo J, Bruix J, Charco R.
Ann Surg 2014 May;259(5):944-52.
Impact factor: 7,18
“Very early” intrahepatic cholangiocarcinoma in cirrhotic patients: should liver transplantation be reconsidered in these patients?
Sapisochin G, Rodríguez de Lope C, Gastaca M, Ortiz de Urbina J, Suarez MA, Santoyo J, Castroagudín JF, Varo E, López-Andujar R, Palacios F, Sanchez Antolín G, Perez B, Guiberteau A, Blanco G, González-Diéguez ML, Rodriguez M, Varona MA, Barrera MA, Fundora Y, Ferron JA, Ramos E, Fabregat J, Ciria R, Rufian S, Otero A, Vazquez MA, Pons JA, Parrilla P, Zozaya G, Herrero JI, Charco R, Bruix J.
Am J Transplant. 2014 Mar;14(3):660-7.
Impact factor: 6,19
Indocyanine green plasma disappearance rate: a new tool for the classification of paediatric patients with acute liver failure.
Quintero J, Miserachs M, Ortega J, Bueno J, Dopazo C, Bilbao I, Castells L, Charco R.
Liver Int 2014 May;34(5):689-94
Impact factor: 4,44
Etiology and mortality of spontaneous bacterial peritonitis in liver transplant recipients: a cohort study.
Pérez-Cameo C, Vargas V, Castells L, Bilbao I, Campos-Varela I, Gavaldà J, Pahissa A, Len O.
Liver Transpl. 2014 Jul;20(7):856-63.
Impact factor: 3,79
Liver biopsy-related infection in liver transplant recipients: A current matter of concern?
Sánchez CL, Len O, Gavalda J, Bilbao I, Castells L, Gelabert MA, Allende H, Pahissa A.
Liver Transpl. 2014 May;20(5):552-6
Impact factor: 3,79
MAIN RESEARCH PROJECTS
ViewEstudio multicéntrico, aleatorizado, abierto, controlado, de 12 meses de seguimiento para evaluar el impacto en la función renal de un régimen inmunosupresor basado en la minimización de tacrolimus en asociación con everolimus en pacientes receptores de un trasplante hepático de novo. Estudio REDUCE.
Código Protocolo: CRAD001HES01
Número EudraCT: 2013-001191-38
A 24-month, multi-center, single arm, prospective study to evaluate renal function, efficacy, safety and tolerability of everolimus in combination with reduced exposure cyclosporine or tacrolimus in paediatric liver transplant recipients.
Rol of the intestinal microbiota on the early outcome of human liver transplantation. A prospective study.
PG(AG)321/2013
ClinicalTrials.Gov Identifier : NCT02223468
Single centre, prospective, open, non controlled, pilot study for efficacy and security evaluation of low nephrotoxicity immunosuppression, based on the use of ATeGe- FRESENIUS, in liver transplant candidates with pretransplant renal insufficiency.
Protocol code ATG-IRA-HVH.10, Eudra CT 2011-000691-34
ClinicalTrials.Gov Identifier : NCT 01453218
A prospective randomised, open-labeled, trial comparing sirolimus-containing vs mTOR-inhibitor-free inmmunosuppression in patients undergoing liver transplantation for hepatocellular carcinoma.
EudraCT No.: 2005-005362-36
ClinicalTrials.gov Identifier : NCT 00355862
Protocol No.: SiLVER 05
Rol of the intestinal microbiota on the early outcome of human liver transplantation. A prospective study.
PG(AG)321/2013
ClinicalTrials.Gov Identifier : NCT02223468