Respiratory and Systemic Diseases
Chronic Fatigue
Dr. José Alegre-Martín
Researchers
Naia Sáez-Fràncas, Natalia Calvo Piñero, Jesús Castro-Marrero, Mónica Faro
Nursing, Techinical and Administrative staff
Luisa Aliste, Amelia Marquino
SUMMARY
During 2014, our group has worked on:
– Neuropsychopathology impairments and association with clinical predisposing factors in Chronic Fatigue Syndrome/Myalgic Encephalomielitis (CFS/ME). Cognitive dysfunction in CFS/ME could be explained by pathophysiological events of the disease. It’s needed to identify homogeneous subgroups of patients with CFS/ME by common factors, which help to identify more specific cognitive profiles as individualized potential therapeutic strategies.
– CFS/ME and personality. The results of this study are consistent with existing data of the relationship between neuroticism and CFS / ME.
– Analysis of Single Nucleotide Polymorphisms (SNP) and Copy Number Variation (CNV) in Fibromyalgia (FMS). The results of genomic study by GWAS and aCGH point to a key role of the central nervous system (brain) in patients with major genetic susceptibility factors to FMS.
Impact of Fibromyalgia (FMS) in patients with CFS/ME. The comorbidity of FMS worse clinical symptoms, fatigue and quality of life of CFS/ME patients.
PUBLICATIONS
- Sáez-Francàs N, Valero S, Calvo N, Gomà-I-Freixanet M, Alegre J, de Sevilla TF, Casas M. Chronic fatigue syndrome and personality: a case-control study using the Alternative Five Factor Model. Psychiatry Res 2014; 216(3):373-8. IF: 2.682
- Docampo E, Escaramís G, Gratacòs M, Villatoro S, Puig A, Kogevinas M, Collado A, Carbonell J, Rivera J, Vidal J, Alegre J, Estivill X, Rabionet R. Genome-wide analysis of single nucleotide polymorphisms and copy number variants in fibromyalgia suggest a role for the central nervous system. Pain 2014; 155(6):1102-9. IF: 5.836
- Faro M, Sáez-Francàs N, Castro-Marrero J, Aliste L, Collado A, Alegre J. Impact of the fibromyalgia in the chronic fatigue syndrome. Med Clin (Barc) 2014; 142(12):519-25. IF: 1.252
- Sáez-Francàs N, Hernández-Vara J, Corominas-Roso M, Alegre J, Jacas C, Casas M. Relationship between poor decision-making process and fatigue perception in Parkinson’s disease patients. J Neurol Sci 2014; 337(1-2):167-72. IF: 2.262
- Santamarina-Perez P, Eiroa-Orosa FJ, Rodriguez-Urrutia A, Qureshi A, Alegre J. Neuropsychological impairment in female patients with chronic fatigue syndrome: a preliminary study. Appl Neuropsychol Adult 2014;21(2):120-7. IF: 1.971
MAIN RESEARCH PROJECTS
View- Genome-Wide Association Study (GWAS) of CFS/ME and FMS in Spanish population. In collaboration with the Spanish Genetic and Clinical Data Bank for CFS/ME and FMS, Spanish Foundation FF and Genomics and Disease Working Group, Center for Genomic Regulation (CRG) in Barcelona, Spain.
- Neuropsychological impairment in females with CFS. In collaboration with Neuropsychology Unit, Vall d’Hebron Hospital Research Institute, Barcelona, Spain.
- Screening NK, B and T-cell phenotype and function in Spanish CFS patients. In collaboration with Cell Virology and Immunology Working Group, AIDS Research Institute (IrsiCaixa – HIVACAT). Institut d’Investigació en Ciències de la Salut Germans Trias I Pujol, Badalona, Spain.
- The central fatigue in Parkinson’s disease. In collaboration with the Parkinson Study Group, Department of Psychiatry and Neurology, Vall d’Hebron University Hospital, Barcelona, Spain.
- Bioenergetic metabolism, oxidative stress and immune response after supplementation with CoQ10 plus NADH in CFS patients. In collaboration with VITAE NATURAL NUTRITION, SL and Sevilla University School of Medicine, Universidad de Sevilla, Spain.
- Study protocol for a clinical trial, randomized, controlled, parallel, to evaluate the effectiveness of acupuncture intervention in the treatment of CFS patients. In collaboration with the College of Nursing of Barcelona (COIB), Spain.