Digestive and Liver Diseases
Physiology and Pathophysiology of the Digestive Tract
Fernando Azpiroz
Researchers
Ana María Accarino Garaventa, Carmen Alonso Cotoner, Natalia Borruel Sainz, Francesc Casellas Jordá, Francisco Guarner Aguilar, Beatriz Lobo Álvarez, Carolina Malagelada Prats, Chaysavanh Manichanh , Francesc Xavier Molero Richard, Javier Santos Vicente, Maria Vicario Pérez, Jaume Vilaseca Momplet
Researchers in training
Barbara Ciccantelli , Claudia Maria Herrera de Guise, Suchita Panda , Virginia Robles Alonso, Eloísa Salvo Romero, Encarna Varela Castro, Ana Maria González Castro , Bruno Kotska Rodiño Janeiro
Nursing, Technical and Administrative Staff
Raimunda Carmen Alastrue Borbón, Elisabeth Barba Orozco, Milagros Gallart Mora, Josefa Mª Heredia Montiel, Xavier Martínez Serrano, Laura Molne Aricha, Adoración Nieto Ruiz, Gloria Santaliestra Vivaracho, Alba Santiago Badenas, César Javier Sevillano Aguilera
SUMMARY
Idiopathic digestive symptoms have been categorized as functional gastrointestinal disorders. With our research program we have obtained evidence on the organic-type alterations underlying these disorders. In 2014 advances in three key fronts have been achieved. First, patients with functional gastrointestinal disorders have a labile microbiota that reacts abnormally to a challenge diet. In this line, we participated in a comprehensive international investigation within the EC-funded MetaHit consortium developing an integrated catalogue of reference genes in the human gut microbiota, which is key to interpret the abnormalities found in patients. Second, new evidence was obtained on the abnormalities of humoral immunity related to abnormal barrier function in patients with diarrhea and abdominal symptoms. Finally, we have identified that some symptoms in patients with functional gastrointestinal disorders are in reality somatic responses to visceral stimuli, and interestingly, these symptoms can be corrected by behavioral therapy.
PUBLICATIONS
- Anal gas evacuation and colonic microbiota in patients with flatulence: effect of diet.
Manichanh C, Eck A, Varela E, Roca J, Clemente JC, Gonzalez A, Knights D, Knight R, Estrella S, Hernandez C, Guyonnet D, Accarino A, Santos J, Malagelada JR, Guarner F, Azpiroz F. Gut. 2014 Mar;63(3):401-8. doi: 10.1136/gutjnl-2012-303013. Epub 2013 Jun 13. - Mechanisms of postprandial abdominal bloating and distension in functional dyspepsia.
Burri E, Barba E, Huaman JW, Cisternas D, Accarino A, Soldevilla A, Malagelada JR, Azpiroz F. Gut. 2014 Mar;63(3):395-400. doi: 10.1136/gutjnl-2013-304574. Epub 2013 May 4. - An integrated catalog of reference genes in the human gut microbiome.
Li J, Jia H, Cai X, Zhong H, Feng Q, Sunagawa S, Arumugam M, Kultima JR, Prifti E, Nielsen T, Juncker AS, Manichanh C, Chen B, Zhang W, Levenez F, Wang J, Xu X, Xiao L, Liang S, Zhang D, Zhang Z, Chen W, Zhao H, Al-Aama JY, Edris S, Yang H, Wang J, Hansen T, Nielsen HB, Brunak S, Kristiansen K, Guarner F, Pedersen O, Dore J, Ehrlich SD, Bork P, Wang J, Pons N, Le Chatelier E, Batto JM, Kennedy S, Haimet F, Winogradski Y, Pelletier E, LePaslier D, Artiguenave F, Bruls T, Weissenbach J, Turner K, Parkhill J, Antolin M, Casellas F, Borruel N, Varela E, Torrejon A, Denariaz G, Derrien M, van Hylckama Vlieg J, Viega P, Oozeer R, Knoll J, Rescigno M, Brechot C, M’Rini C, Merieux A, Yamada T, Tims S, Zoetendal EG, Kleerebezem M, de Vos WM, Cultrone A, Leclerc M, Juste C, Guedon E, Delorme C, Layec S, Khaci G, van de Guchte M, Vandemeulebrouck G, Jamet A, Dervyn R, Sanchez N, Blottiere H, Maguin E, Renault P, Tap J, Mende DR. Nat Biotechnol. 2014 Aug;32(8):834-41. doi: 10.1038/nbt.2942. Epub 2014 Jul 6. - Increased humoral immunity in the jejunum of diarrhoea-predominant irritable bowel syndrome associated with clinical manifestations.
Vicario M, Gonzalez-Castro AM, Martinez C, Lobo B, Pigrau M, Guilarte M, de Torres I, Mosquera JL, Fortea M, Sevillano-Aguilera C, Salvo-Romero E, Alonso C, Rodino-Janeiro BK, Soderholm JD, Azpiroz F, Santos J. Gut. 2014 Sep 10. pii: gutjnl-2013-306236. doi: 10.1136/gutjnl-2013-306236. - Abdomino-Thoracic Mechanisms of Functional Abdominal Distension And Correction by Biofeedback.
Barba E, Burri E, Accarino A, Cisternas D, Quiroga S, Monclus E, Navazo I, Malagelada JR, Azpiroz F . Gastroenterology. 2014 Dec 11. pii: S0016-5085(14)01531-5. doi: 10.1053/j.gastro.2014.12.006.
MAIN RESEARCH PROJECTS
View- European Training in Neural Regulation of Intestinal Function Grant agreement nº: 607652. NEUROGUT_FP7ITN. Azpiroz Vidaur, Fernando
- Unitat de Recerca del Sistema Digestiu (GRC. 2014 SGR 1285). AGAUR. Azpiroz Vidaur, Fernando
- Reshaping the Gut Microbiota for Health. CP13/00181. Fondo de Investigación Sanitaria. Manichanh , Chaysavanh
- Mecanismos neuroinmunológicos de activación de la respuesta humoral en la fisiopatología del Síndrome del Intestino Irritable: base orgánica de la disfunción intestinal. PI13/00935. Fondo de Investigación Sanitaria. Vicario Perez, Maria
- Neurofisiología y neurofisiopatología digestiva. SAF2013-43677-R. Ministerio de Economía y Competitividad. Azpiroz Vidaur, Fernando