Gynecology, Pediatric Diseases and Experimental Surgery
Musculoskeletal Tissue Engineering
Màrius Aguirre Canyadell
Researchers
Sergi Barrera Ochoa, Diego Collado Gastalver, Daniel Alejandro Pacha Vicente, Roberto Vélez Villa.
Researchers in training
Marc Aguilar García, Víctor Barro Ojeda, Irene Gallardo Calero, Alba López Fernández.
Nursing, technical and administrative staff
Noemí García López.
SUMMARY
One of the main goals in 2014 has been the finalization of our project “Viability study of the microsurgical vascular anastomosis in an irradiated population in an animal model in rats” which has been the subject matter of the doctoral thesis of Dr. Sergi Barrera Ochoa. With this study we can demonstrate that the effect of external radiotherapy can be the main cause of microvascular free flap failure in a context of extern neoadjunvant irradiation, because its application increases the incidence of venous thrombosis.
PUBLICATIONS
- Barrera-Ochoa S, Muñetón D, Mir X. Periprosthetic proximal fracture in total wrist arthroplasty.
J Hand Surg Am. 2014 Feb;39(2):399-400. doi: 10.1016/j.jhsa.2013.12.010. - Barrera-Ochoa S, Vidal-Tarrason N, Correa-Vázquez E, Reverte-Vinaixa MM, Font-Segura J, Mir-Bullo X. Pyrocarbon interposition (PyroDisk) implant for trapeziometacarpal osteoarthritis: minimum 5-year follow-up. J Hand Surg Am. 2014 Nov;39(11):2150-60. doi: 10.1016/j.jhsa.2014.07.011. Epub 2014 Sep 11.
- Soldado F, Knörr J, Haddad S, Corona PS, Barrera-Ochoa S, Collado D, Mascarenhas VV, de Gauzy JS. Vascularized tibial periosteal graft in complex cases of bone nonunion in children. Microsurgery. 2015 Mar;35(3):239-43. doi: 10.1002/micr.22342. Epub 2014 Oct 18.
- 4. Pellisé F, Barastegui D, Hernandez-Fernandez A, Barrera-Ochoa S, Bagó J, Issa-Benítez D, Cáceres E, Villanueva C. Viability and long-term survival of short-segment posterior fixation in thoracolumbar burst fractures. Spine J 2014 Mar 15. pii: S1529-9430(14)00253-8. doi: 10.1016/j.spinee.2014.03.012.
- 5. Garcia M, Velez R, Romagosa C, Majem B, Pedrola N, Olivan M, Rigau M, Guiu M, Gomis RR, Morote J, Reventós J, Doll A. Cyclooxygenase-2 inhibitor suppresses tumour progression of prostate cancer bone metastases in nude mice. BJU Int. 2014 May;113(5b):E164-77. doi: 10.1111/bju.12503. Epub 2014 Feb 14.
MAIN RESEARCH PROJECTS
View- Femoral head osteonecrosis treatment with advanced cell therapy and biomaterials in an experimental sheep animal model.
PI: Aguirre Canyadell, Mario
Funding agency: Fundació La Marató de TV3
Reference: 61/C/2012
Funding: 200.000,00 €
Duration: from 2013 to 2016 - Estudio experimental de terapia celular con células madre adultas expandida “in vivo”
PI: Aguirre Canyadell, Mario
Funding agency: Fondo de Investigación Sanitaria
Reference: PI11/02231
Funding: 79.255,00 €
Duration: from 2012 to 2015 - Terapia celular autóloga con células madre adultas en la osteonecrosis de la cabeza femoral
PI: Aguirre Canyadell, Mario
Funding agency: Ministerio Sanidad Servicios Sociales e Igualdad
Reference: EC10-208
Funding: 250.000,00 €
Duration: from 2011 to 2015 - Estudio sobre la viabilidad de la anastomosis vascular microquirúrgica en población irradiada. Estudio en modelo animal en rata
PI: Vélez Villa, Roberto
Funding agency: Fundación SECOT
Reference: SECOT-2012-01
Funding: 12.000,00 €
Duration: from 2012 to 2014 - Anàlisi de la revitalització en empelts estructurals d’os criopreservat associat a penjoll periòstic vascularitzat. Model animal a rata
PI: Aguirre Canyadell, Mario
Funding agency: Societat Catalana de Cirurgia
Reference: SCCOT-2014-01
Funding: 12.000,00 €
Duration: from 2014 to 2015
PATENTS
- Pla A, Garcia J, Caminal M, Vives J, Garcia J, Aguirre M: “Procedimiento para la obtención de un producto de ingeniería tisular orientado a la regeneración de tejido óseo”.
Procedure for obtaining a tissue engineered product oriented bone tissue regeneration. The present invention relates to a process for the preparation of a tissue engineered product oriented bone tissue regeneration. More particularly, the present invention relates to a product comprised mainly of expanded bone mesenchymal origin immobilized on bone supports and amalgamated by fibrin gels. Said process essentially comprises the steps of colonization and bone supports amalgamated settled particles based on fibrin gels.Ref. no.: 201030238/9
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