Cardiovascular Diseases
Cardiocirculatory Pathology
David García-Dorado
Researchers
Santiago Aguade Bruix, X. Armengol Castell, Jordi Bañeras Rius, Ignasi Barba Vert, Neus Bellera Gotarda, José Antonio Barrabés Riu, Joan Castell Conesa, José Antonio Castellano Abarca, Amanda Denuc Isern, Enric Domingo Ribas, Laura Dos Subirà, Arturo Evangelista Masip, Ignacio Ferreira González, Jaume Figueras Bellot, Laura Galián Gay, Enrique Galve Basilio, Bruno García del Blanco, Josep Maria Girona Comas, Teresa González Alujas, Laura Gutierrez Garcia-Moreno, Javier Inserte Igual, Rosa María Lidón Corbi, Gerard Martí Aguasca, Angel Moya Mitjans, Imanol Otaegui Irurueta, Gaietà Permanyer Miralda, Jordi Pérez Rodón, Antonia Pijuan Domenech, Josep Pinar Sopena, Marcos Poncelas Nozal, Ivo Roca Luque, Jose Fernando Rodríguez Palomares, Antonio Rodriguez Sinovas, Aida Ribera Solé, Núria Rivas Gándara, Marisol Ruiz Meana, Ivo Roca Luque, Antonia Sambola Ayala, Jaume Sagristà Sauleda, Vicente Serra Garcia, G. Teixidó Turà, Pilar Tornos Mas
Researchers in training
Gabriel Acosta Velez, Juan José Alburquerque Bejar, David Aluja González, Mireia Andres Villarreal, Jordi Bañeras Rius, Celia Fernández Sanz, Jaume Francisco Pascual, Marta Minguet, Elisabet Miro Casas, Berta Miranda Barrios, Maria Nazarena Pizzi, Agnès Rafecas Ventosa, Úrsula Vilardosa Vila, Giuliana Maldonado, Alba Santos Ortega
Nursing, Technical, and Administrative Staff
Mª Ángeles Carmona Ramírez, Anna Casanovas Hernandez, Purificació Cascant Castelló, Úrsula Gimeno Mañas, Daniel Gómez García, Josep Ramon Marsal Mora, Lourdes Muela Godoy, Elsa Nieto Santa, Ángeles Rojas López, Rosalía Coronado González, Giuliana Rios Quiñones
SUMMARY
During 2014, our group published several articles that were unique in several important features. One example is the publication of our first investigator-driven clinical trial in the area of prevention of reperfusion injury in acute myocardial infarction, a research line in which we have published a large number of preclinical studies. The PROMISE randomized, double blinded placebo-controlled clinical trial tested the effect of intracoronary adenosine at the time of primary angioplasty on infarct size determined by cardiac MRI, and found a reduction of infarct size in patients arriving within 3 hours of chest pain.
The past year saw also the take-off of several unique projects and grants. A very important one was the Integrative Project of Excellence of the ISCiii aimed to prevent ischemic cardiovascular events and to limit its magnitude in patients with diabetes, coordinated by our group with seven other groups of VIRH.
Finally, we opened in 2014 the Biobank of the Cardiology Department, a key structure for our translational research program. We have started rapidly growing collections of samples of aortic tissue from different research projects of our research line on aortic diseases, on blood from patients in studies on ischemic heart disease and congenital heart diseases in adolescent and adult patients, and expect to include samples from other national and an international studies in the next future.
PUBLICATIONS
- Garcia-Dorado D, Garcia-Del-Blanco B, Otaegui I, Rodriguez-Palomares J, Pineda V, Gimeno F, Ruiz-Salmeron R, Elizaga J, Evangelista A, Fernandez-Aviles F, San Roman A, Ferreira-Gonzalez I. Intracoronary injection of adenosine before reperfusion in patients with ST-segment elevation myocardial infarction: A randomized controlled clinical trial. Int J Cardiol 2014;177:935-941. PM:25449504
- Inserte J, Hernando V, Ruiz-Meana M, Poncelas-Nozal M, Fernandez C, Agullo L, Sartorio C, Vilardosa U, Garcia-Dorado D. Delayed phospholamban phosphorylation in post-conditioned heart favours Ca2+ normalization and contributes to protection. Cardiovasc Res 2014; 103:542-53. PM:25020913
- Perez-Rodon J, Martinez-Alday J, Baron-Esquivias G, Martin A, Garcia-Civera R, Del Arco C, Cano-Gonzalez A, Moya-Mitjans A. Prognostic Value of the Electrocardiogram in Patients with Syncope: Data from the Group for Syncope Study in the Emergency Room (GESINUR). Heart Rhythm 2014; 11:2035-44. PM:24993462
- Pijuan-Domenech A, Pineda V, Castro MA, Sureda-Barbosa C, Ribera A, Cruz LM, Ferreira-Gonzalez I, Dos-Subira L, Subirana-Domenech T, Garcia-Dorado D, Casaldaliga-Ferrer J. “Pulmonary valve replacement diminishes the presence of restrictive physiology and reduces atrial volumes”: A prospective study in Tetralogy of Fallot patients. Int J Cardiol 2014;177:261-265. PM:25499390
- Teixido-Tura G, Redheuil A, Rodriguez-Palomares J, Gutierrez L, Sanchez V, Forteza A, Lima JA, Garcia-Dorado D, Evangelista A. Aortic biomechanics by magnetic resonance: Early markers of aortic disease in Marfan syndrome regardless of aortic dilatation? Int J Cardiol 2014;171:56-61. PM:24332599
MAIN RESEARCH PROJECTS
View- Terapia combinada con condicionamiento isquémico remoto y tratamiento metabólico para la prevención del daño por reperfusión en el infarto de miocardio. Eficacia en pacientes diabéticos
PI: García-Dorado García, David
Funding agency: Fondo de Investigación Sanitaria
Reference: PI14/01431
Funding: 125.235,00 €
Duration: 2015 to 2017 - Preventing cardiovascular ischemic events and arresting their consequences in type 2 diabetic population: a multidisciplinary clinical and experimental approach
PI: García-Dorado García, David
Funding agency: Fondo de Investigación Sanitaria
Reference: PIE13/00027
Funding: 825.000,00 € - DISCHARGE “Diagnostic Imaging Strategies for Patients with Stable Chest Pain and Intermediate Risk of Coronary Artery Disease: Comparative Effectiveness Research of Existing Technologies” Grant agreement nº 603266 Grant Agreement nº 603266
PI: Rodríguez Palomares, Jose Fernando
Funding agency: European Commission
Reference: DISCHARGE_FP7HEALTH2013
Funding: 155.080,00 €
Duration: from 2014 to 2018 - Papel de los microdominios celulares en el deterioro de la función cardíaca durante el envejecimiento y su menor tolerancia al estrés.
PI: Ruiz Meana, Marisol
Funder Entity: Fondo de Investigación Sanitaria
Reference: PI12/00788
Funding: 210.540,00 €
Duration: from 2013 to 2015 - Red Cardiovascular
PI: García-Dorado García, David
Funder Entity: Fondo de Investigación Sanitaria
Reference: RD12/0042/0021
Funding: 789.338,27€
Duration: from 2013 to 2016