Gynecology, Pediatric Diseases and Experimental Surgery

Ophthalmology

José García-Arumí

Researchers
Anna Boixadera Espax, Laura Distefano, Carme Macià Badia, Vicente Martínez- Castillo, Miguel Ángel Zapata Victori, Daniel Velázquez, Marta Castany, Laia Bisbe.

Researchers in training
Anna Salas Torras, Laura Fontrodona.

Nursing, Technical and administrative staff
Natalia de Dios Milla i Ferran Casals Riera.

SUMMARY

Within the broad range of tests performed in the unit included the identifications of biomarkers in patients with AMD (age-related Macular Degeneration) treated with aflibercept and the development of prospective studies in patients with diabetic retinopathy treated with eye drops,…

In this sense, the group aims to be a leader in the development of clinical trials promoting the training and certifications of personnel. In fact, our team has recently been certified by the European Clinical Vision Research (AVICR) in recognition of research excellence in the clinical field.

We are researching in new therapies with experimental animal models. The laboratory currently has several lines of research, all financed. In particular, the laboratory is developing a non-viral gene therapy in a rat model for diabetic retinopathy, a cell therapy that combines photoreceptor and RPE transplant in a rat model for retinitis pigmentosa, a topical treatment with fractions of synthetic Pigment Epithelium Derived Factor (PEDF) in a mouse model for the wet form of AMD and a non-viral gene therapy in two mouse models for wet and dry forms of AMD.

PUBLICATIONS

Total 8.
Impact Factor 24.671
Average I.F. 3.084

  • García-Layana A, Arias L, Figueroa MS, Araiz J, Ruiz-Moreno JM, Garcia-Arumí, J., , Gómez-Ulla F, López-Gálvez MI, Cabrera-López F, García-Campos JM, Monés J, Cervera E, Armadá F, Gallego-Pinazo R, Piñero-Bustamante A, Serrano-Garcia MA. A delphi study to detect deficiencies and propose actions in real life treatment of neovascular age-related macular degeneration. Journal of Ophthalmoly. 2014;2014:595132. doi: 10.1155/2014/595132. Epub 2014 Dec 21. IF: 1.935
  • Medeiros MD, Alkabes M, Navarro R, Garcia-Arumí, J., , Mateo C, Corcóstegui B. Dexamethasone intravitreal implant in vitrectomized versus nonvitrectomized eyes for treatment of patients with persistent diabetic macular edema. J Ocul Pharmacol Ther. 2014 Nov;30(9):709-16. doi: 10.1089/jop.2014.0010. Epub 2014 Sep 26. IF: 1.42
  • Bogdanov P, Corraliza L, Villena JA, Carvalho AR, Garcia-Arumí, J., , Ramos D, Ruberte J, Simó R, Hernández C. The db/db mouse: a useful model fot the study of diabetic retinal neurodegeneration. PLoS One. 2014 May 16;9(5):e97302. doi: 10.1371/journal.pone.0097302. eCollection 2014. IF: 3.534
  • Casaroli-Marano R, Gallego-Pinazo R, Fernández-Blanco CT, Figueroa MS, Pina Marín B, Fernández-Baca Vaca G, Piñero-Bustamante A, Donate López J, Garcia-Arumí, J., , Farrés Martí J. Age-Related Macular Degeneration: Clinical Findings following Treatment wiht Antiangiogenic Drugs. J Ophthalmol. 2014;2014:346360. doi: 10.1155/2014/346360. Epub 2014 Feb 16. IF: 1.935
  • Dutra Medeiros M., Postorino M., Navarro R., Garcia-Arumí, J., Mateo C., Corcóstegui B. Dexamethasone intravitreal implant for treatment of patients with persistent diabetic macular edema. Ophthalmologica. 2014;231(3):141-6. doi: 10.1159/000356413. Epub 2013 Dec 19. IF: 1.867

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MAIN RESEARCH PROJECTS

  • Non-viral gene therapy with Pigment Epithelium-Derived Factor (PEDF) for the treatment of dry and wet forms of Age-Related Macular Degeneration (AMD)
    ISCIII – FIS grant 2014 – PI14/00999 – INDIVIDUAL PROJECT
    Start-End: 2015-2017
    IP: José García-Arumí
  • Active Fractions of Pigment Epithelium Derived Factor (PEDF) in the treatment of choroidal neovascularization in an animal model of Age-Related Macular Degeneration.
    ISCIII – FIS grant 2013 – PI13/0096 – INDIVIDUAL PROJECT
    Start-End: 2014-2016
    IP: Anna Boixadera
  • Cell therapy with Retinal Pigment Epithelium Cells and Photoreceptors differentiated from pluripotent stem cells in a rat model of Retinitis Pigmentosa.
    Fundació La Marató de TV3 – 2012 grant – COORDINATED PROJECT
    Start-End: 2013-2015
    IP: José García-Arumí

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